Dr. Sai is a distinguished Ghanaian physician. He received the 1993 United Nations Population Award and the 1995 Prince Mahidol Award in recognition of his long-standing involvement and global leadership on international family planning and population issues.

Since co-founding the Planned Parenthood Association of Ghana in 1967, Dr. Sai has been affiliated with several leading international organizations working in the population and reproductive health field. From 1989 to 1995, he was President of the International Planned Parenthood Federation (IPPF). He held that post after serving as Senior Population Advisor at the World Bank and working with the Food and Agriculture Organization and other intergovernmental organizations. Dr. Sai is perhaps most well known for his able Chairmanship of the last two major UN conferences on population and development held in Mexico City in 1984 and Cairo in 1994.

He served in several positions in the Ghana Health Services, including being Chief Physician for Nutrition and the Director of Medical Services. He was also a Professor of Preventive and Social medicine at the University of Ghana Medical School. The author and editor of numerous publications relating to family planning, health and nutrition, Dr. Sai now serves as an advisor to the President and Government of Ghana on Reproductive Health and HIV/AIDS.  In 1998, Dr. Sai received the Harvard School of Public Health Alumni Award of Merit for his outstanding contributions to the field of public health; this award is the highest honor the school bestows on its alumni. He published his memoirs in 2010 With Heart and Voice: Fred Sai Remembers.